Volume: 46 Issue: 2
Year: 2026, Page: 113-118, Doi: https://doi.org/10.51248/v46i2.15
Received: Feb. 2, 2026 Accepted: May 30, 2026 Published: June 7, 2026
Background: Type 2 Diabetes Mellitus (TDM) is a chronic metabolic disorder marked by hyperglycemia. Calcium plays a crucial role in insulin secretion and glucose metabolism, yet the relationship between serum calcium levels and diabetes mellitus remains unclear, warranting further exploration. Objective: This study aims to assess and compare serum calcium levels in T2DM patients and healthy controls in the Kodagu district, hypothesizing significant differences that could influence clinical management and public health. Methods: Conducted from December 2022 to March 2025 at the Kodagu Institute of Medical Sciences, this hospital-based, cross-sectional study included 200 participants-100 with T2DM and 100 age-matched controls. Blood samples were collected and analyzed for serum calcium levels, fasting blood glucose and HbA1c. Statistical analyses were performed using SPSS software. Results: Patients with T2DM had a mean serum calcium level of 8.45 ± 0.75 mg/dL, significantly lower than the 9.25 ± 0.73 mg/dL observed in controls (p < 0.01). Conclusion: Decreased calcium levels in T2DM patients suggest impaired calcium homeostasis, emphasizing the need for monitoring and potential supplementation to improve glucose management strategies. Further research is needed to understand these associations better.
Keywords: Calcium, Diabetes Mellitus, Cross-Sectional Studies.
1. Hossain MJ, Al‐Mamun M, Islam MR. Diabetes mellitus, the fastest growing global public health concern: Early detection should be focused. Health Sci Rep. 2024 Mar 22;7(3):e2004.
2. Zhou B, Rayner AW, Gregg EW, Sheffer KE, Carrillo-Larco RM, Bennett JE, Shaw JE, Paciorek CJ, Singleton RK, Pires AB,
Stevens GA. Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. The Lancet. 2024 Nov 23;404(10467):2077-93.
3. Wilmot E, Idris I. Early onset type 2 diabetes: risk factors, clinical impact and management. Ther Adv Chronic Dis. 2014 Nov;5(6):234-44.
4. Klec C, Ziomek G, Pichler M, Malli R, Graier WF. Calcium Signaling in ß-cell Physiology and Pathology: A Revisit. Int J Mol Sci. 2019 Dec 4;20(24):6110.
5. Zhu J, Xun P, Bae JC, Kim JH, Kim DJ, Yang K, He K. Circulating calcium levels and the risk of type 2 diabetes: a systematic review and meta-analysis. Br J Nutr. 2019 Aug;122(4):376-87.
6. Rooney MR, Pankow JS, Sibley SD, Selvin E, Reis JP, Michos ED, et al., Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study. Am J Clin Nutr. 2016 Oct;104(4):1023-9.
7. Hajhashemy Z, Rouhani P, Saneei P. Dietary calcium intake in relation to type-2 diabetes and hyperglycemia in adults: A systematic review and dose-response meta-analysis of epidemiologic studies. Sci Rep. 2022 Jan 20;12(1):1050.
8. Shah IU, Sameen A, Manzoor MF, Ahmed Z, Gao J, Farooq U, et al., Association of dietary calcium, magnesium, and vitamin D with type 2 diabetes among US adults: National health and nutrition examination survey 2007-2014-A cross‐sectional study. Food Sci Nutr. 2021 Jan 27;9(3):1480-90.
9. American Diabetes Association Professional Practice Committee for Diabetes. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2026. Diabetes Care. 2026 Jan 1;49(Supplement_1):S27-S49.
10. ZAS G HM, El-S A, Asmaa Y, El-SK M. Assessment of HbA1c%, Serum Calcium, Magnesium Levels in Egyptian (Cairo gov.) Diabetic Type 2 Patients. J Biol Med. 2025;9(1):003-7.
Chen J min, Wu T yin, Wu Y fan, Kuo K liang. Association of the serum calcium level with metabolic syndrome and its components among adults in Taiwan. Arch Endocrinol Metab. 2023 May 29;67(5):e000632.
12. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2007 June 1;92(6):2017-29.
13. Nwankwor HC, Nwatu CB, Okwara CC, Young EE, Olisaka LC, Ezomike NC, et al., Low serum calcium levels occur in Nigerian adults with type 2 diabetes and correlates negatively with their glycosylated hemoglobin levels: a case‑control study. Nigerian Journal of Medicine. 2020 Jul 13;29(2):229-33.
14. Ganesan H, Arumugham Dhanaraj S, Aishwarya T. A cross-sectional study correlating serum calcium levels and the state of control of Type 2 Diabetes Mellitus. Public Health Rev Int J Public Health Res. 2019;6(6):246-251.
15. Faysal MR, Akter T, Hossain MS, Begum S, Banu M, Tasnim J, et al., Study of Serum Calcium and Magnesium Levels in Type 2 Diabetes Mellitus Patients. Mymensingh Med J. 2023 Jan 1;32(1):54-60.
16. Kravchenko VІ, Ivaskiva KY, Andrusyshyna IM, Pankiv VI, Khalangot MD, Orlenko VL, et al., Assessment of serum calcium, magnesium and zinc levels in patients with type 2 diabetes mellitus in the Ukrainian population. International Journal of Endocrinology (Ukraine). 2023 Nov 30;19(7):505-9.
17. Itam AH, Ogarekpe YM, Edem B, Agboola AR, Okpara HC, Okokon EO. Association between Serum Calcium Concentration and Glycated Haemoglobin in Type II Diabetic Nigerian Patients. BIOMED Nat Appl Sci. 2022 Dec;02(03):25-32.
18. Zhu H, Wang H, Jia Y, Cheng L, Cheng X. Increased serum calcium levels are associated with carotid atherosclerotic plaque in normocalcaemic individuals with type 2 diabetes. Ther Adv Endocrinol Metab. 2021 Mar;12:2042018821995369.
19. Yu Q, Xu L, Liang C, Deng Y, Wang P, Yang N. Association of serum calcium levels with diabetic kidney disease in normocalcemic type 2 diabetes patients: a cross-sectional study. Sci Rep. 2024 Sep 14;14:21513.
20. Najeeb Q, Aziz R, Hamid S. To evaluate the levels of glycated hemoglobin, serum calcium, magnesium, phosphate, uric acid and microalbuminuria in patients with newly diagnosed type 2 diabetes mellitus. Int J Res Med Sci. 2014 Oct;2(4):1462-5.
21. Saad MA, Sathyam D, Koora S, Kottireddy S. Vitamin D Supplementation in Deficiency States and Combined Calcium-Vitamin D Therapy in Diabetes Prevention and Management: A Systematic Review of Clinical Evidence. Cureus. 2025 Aug 22;17(8):e90776
22. Hoffmann K, Bryl W, Bhongade B, Avagimyan A, El-Tanani M, Rabbani SA, Talath S, Rangraze IR, Wali AF, Ibraheem W, Satyam SM, Ispas S, Ilias I, Maggio V, Rizzo M, Paczkowska A. Vitamin D supplementation and selected metabolic parameters in patients with type 2 diabetes and obesity: a prospective observational study. Front Endocrinol (Lausanne). 2026 Jan 14;16:1750040.
23. Mitri J, Dawson-Hughes B, Hu FB, Pittas AG. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011 Aug;94(2):486-94.
Manjunath. S. & Rohith. V. Serum Calcium Levels in patients with Type 2 Diabetes Mellitus: A Hospital-Based Cross-Sectional Study in Kodagu District, Karnataka. Biomedicine: 2026, 46(2): 113-118