Volume: 43 Issue: 1
Year: 2023, Page: 364-367, Doi: https://doi.org/10.51248/.v43i01.2655
Introduction and Aim: Thymus atrophy occurs in response to the stress of any etiology such as cold, burn, infection, trauma, pain, and psychogenic stress. The objective of the study is to evaluate the thymus gland in children aged 7–12 years from Kyrgyzstan.
Materials and Methods: The present study assessed the anatomy of the thymus gland on 35 cadavers of children aged 7–12 years from 2015 to 2020. Anatomical methods including preparation, weighing, and measurement, and histological methods including hematoxylin-eosin staining were performed.
Results: In children aged 7–12 years, it was found that in the thickness of the cerebral layer, there is the growth of thymic corpuscles, blood capillaries, and lymphatic slits. The level of cells in the cerebral layer is diverse, there are lymphocytes in large numbers, larger light epithelial and reticular cells, as well as macrophages. In the cortical zone, the cellular composition is mainly lymphoid cells, and mitosis was found in some of them.
Conclusion: In this study, comparatively, the cortical zone prevails over the cerebral one. At this age, the thymus begins to atrophy, as well as the growth of adipose tissue.
Keywords: Thymus gland; thymus atrophy; thymic corpuscles; perivascular spaces; intralobular septa
1. Abaeva T. S. Features of the macro- and microscopic anatomy of the thymus gland in children of early childhood and in the elderly. Vestnik KRSU. 2017;17(10):180-183.
2. Soburov, K. A., Temirova, S. A. Mechanisms of relationship of hormonal and immune systems in adaptation to high altitudes. SNTIK. 2019; 3:131-135.
3. Anderson, G., Jenkinson, E. J. Lymphostromal interactions in thymic development and function. Nat Rev Immunol. 2001;1(1):31-40.
4. Edelmann, S. L., Marconi, P., Brocker, T. Peripheral T cells re-enter the thymus and interfere with central tolerance induction. J Immunol. 2011;186(10):5612-5619.
5. Edwards, T. M., Myers, J. P. Environmental exposures, and gene regulation in disease etiology. Environ Health Perspect. 2007;115(9):1264-1270.
6. Iarmarcovai, G., Botta, A., Orsière, T. Changes in chromosome number, genetic instability, and occupational exposures. Bull Cancer. 2007;94(4):381-388.
7. Love, P. E., Bhandoola, A. Signal integration and crosstalk during thymocyte migration and emigration. Nat Rev Immunol. 2011;11(7):469-477.
8. Farina, A. R., Tacconelli, A., Cappabianca, L., Cea, G., Panella, S., Chioda, A., et al., The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability. Mol Cell Biol. 2009;29(17):4812-4830.
9. Janossy, G., Bofill, M., Trejdosiewicz, L. K., Willcox, H. N., Chilosi, M. Cellular differentiation of lymphoid subpopulations and their microenvironments in the human thymus. Current topics in pathology. Curr Top Pathol. 1986; 75:89-125.
10. Jones, K. L., Hoyme, H. E., Robinson, L. K., Del Campo, M., Manning, M. A., Prewitt, L. M., et al., Fetal alcohol spectrum disorders: Extending the range of structural defects. Am J Med Genet A. 2010;152A(11):2731-2735.
11. Little, R. E., Northstone, K., Golding, J., ALSPAC Study Team. Alcohol, breastfeeding, and development at 18 months. Pediatrics. 2002;109(5): E72-E82.
12. Selye H. A syndrome produced by diverse nocuous agents. Nature. 1936; 138(1):32.
13. Gruver AL, Sempowski GD Cytokines, leptin, and stress-induced thymic atrophy. J. Leukoc. Biol. 2008; 84(4): 915-923.
14. Wodarz D. Ecological and evolutionary principles in immunology. Ecol Lett. 2006;9(6):694-705.
15. Savino, W., Dardenne, M., Velloso, L. A., Dayse Silva-Barbosa, S. The thymus is a common target in malnutrition and infection. Br J Nutr. 2007;98 Suppl 1: S11-S16.
16. Francelin, C., Paulino, L. C., Gameiro, J., Verinaud, L. Effects of Plasmodium berghei on thymus: high levels of apoptosis and premature egress of CD4(+) CD8(+)
thymocytes in experimentally infected mice. Immunobiology. 2011;216(10):1148-1154.
17. Miyamoto, M. S., Miyamoto, Y., Hosokawa, T. Morphological changes of the thymus under stress caused by water immersion and restraint in SAMP1 mice. Int Congr Ser. 2004; 1260:199-202.
18. Elmore S. A. Enhanced histopathology of the thymus. Toxicol Pathol. 2006;34(5):656-665.
19. Malpuech-Brugère, C., Nowacki, W., Gueux, E., Kuryszko, J., Rock, E., Rayssiguier, Y., et al., Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress. Br J Nutr. 1999;81(5):405-411.
20. Kato, S., Schoefl, G. I. Microvasculature of normal and involuted mouse thymus. Light- and electron-microscopic study. Acta Anat (Basel). 1989;135(1):1-11.
Tamara Abaeva, Rustam Tuhvatshin, Masalbek Satybaldiev, Aida Ergeshova, Zarina Toichieva, Siuzana Bakytova. Stages of the evolution of thymus atrophy in children in different cities of Kyrgyzstan. Biomedicine: 2023; 43(1): 364-367