Biomedicine

Abstract

Around the globe, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) pose significant health risks, with a shortage of effective therapeutic options. The potential impact of vitamin E in controlling these conditions has garnered substantial attention. This review aims to evaluate the effects of vitamin E on liver histology, biochemical indicators, and clinical outcomes, examining its influence on the progression of NAFLD and NASH. To identify relevant research, an extensive search was conducted across multiple databases, encompassing observational studies and randomized controlled trials focusing on the impact of vitamin E on NAFLD and NASH. The findings indicate that vitamin E administration may mitigate hepatic steatosis, inflammatory processes, and scarring, demonstrating positive effects on liver histology. However, the observed heterogeneity in outcomes is attributed to variations in research designs, patient demographics, and vitamin E doses. In conclusion, existing data support the consideration of vitamin E as a treatment approach for NAFLD and NASH, particularly in terms of enhancing liver histology. Nevertheless, to offer concrete recommendations regarding the frequency, duration, and potential long-term benefits or risks of vitamin E intake in NAFLD and NASH, more well-designed randomized controlled studies are imperative.