Volume: 46 Issue: 1
Year: 2026, Page: 81-91, Doi: https://doi.org/10.51248/v46i1.194
Received: Sept. 11, 2025 Accepted: March 4, 2026 Published: March 6, 2026
Recent advancements in nanotechnology have revolutionized biomedical research, offering innovative solutions for disease management. The synthesis of silver nanoparticles (AgNPs) using phyto-extracts has gotten significant attention due to its environmentally benign and economical approach. Momordica cymbalaria, a well-known therapeutic properties containing plant, was utilized for the biosynthesis of AgNPs. Extensive phytochemical analyses, including qualitative and quantitative assessments, were conducted to determine the presence of bioactive constituents facilitating nanoparticle synthesis. A range of micro & spectroscopic methods were utilized to characterize the MCAgNPs. Furthermore, their potential anti-inflammatory and anti-oxidant properties were evaluated through in vitro assays. The results suggest that Momordica cymbalaria mediated AgNPs exhibit promising biological activity, making them potential candidates for therapeutic applications in inflammation-related diseases.
Keywords: Momordica cymbalaria, phytochemical, antioxidants, Nanoparticles
1. Gowthami R, Sharma N, Pandey R, Agrawal A. Status and consolidated list of threatened medicinal plants of India. Genet Resour Crop Evol. 2021;68:2235–63. https://doi.org/10.1007/s10722-021-01199-0
2. Anand U, Jacobo-Herrera N, Altemimi A, Lakhssassi N. A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery. Metabolites. Multidisciplinary Digital Publishing Institute; 2019;9:258. https://doi.org/10.3390/metabo9110258
3. Sundar M, Rajagopal G, Nivetha A, Prabu Kumar S, Muthukumar S. Phyto-Mediated Green Synthesis of Silver Nanoparticles Using an Aqueous Leaf Extract of Momordica cymbalaria: Antioxidant, Cytotoxic, Antibacterial, and Photocatalytic Properties. Separations. Multidisciplinary Digital Publishing Institute; 2024;11:61. https://doi.org/10.3390/separations11020061
4. Chinthan KN, Manjunathagowda DC, Rathod V, Devan SR, Anjanappa M. Karchikai (Momordica cymbalaria Hook f.): an untapped cucurbit indigenous to India. Genet Resour Crop Evol. 2021;68:3427–33. https://doi.org/10.1007/s10722-021-01247-9
5. Mohammed FS, Babu D, Irfan Z, Fayed MAA. A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F. PeerJ. PeerJ Inc.; 2024;12:e16928. https://doi.org/10.7717/peerj.16928
6. Hassanpour SH, Doroudi A. Review of the antioxidant potential of flavonoids as a subgroup of polyphenols and partial substitute for synthetic antioxidants. Avicenna J Phytomed. 2023;13:354–76. https://doi.org/10.22038/AJP.2023.21774
7. Afzal MU, Pervaiz M, Ejaz A, Bajwa E, Naz S, Saeed Z, et al., A comprehensive study of the sources, extraction methods and structures of the Saponin compounds for its antidiabetic activity. Biocatalysis and Agricultural Biotechnology. 2023;54:102913. https://doi.org/10.1016/j.bcab.2023.102913
8. Elangovan A, Subramanian A, Durairaj S, Ramachandran J, Lakshmanan DK, Ravichandran G, et al., Antidiabetic and hypolipidemic efficacy of skin and seed extracts of Momordica cymbalaria on alloxan induced diabetic model in rats. Journal of Ethnopharmacology. 2019;241:111989. https://doi.org/10.1016/j.jep.2019.111989
9. Sadat Nasiri S, Pourmadadi M, Rahdar A, Pandey S. Gelatin/PVP/hydroxyapatite nanocomposite based on double microemulsion for tissue engineering applications. Journal of Molecular Liquids. 2024;401:124741. https://doi.org/10.1016 /j.molliq.2024.124741
10. Alhujaily M, Albukhaty S, Yusuf M, Mohammed MKA, Sulaiman GM, AlKaragoly H, et al., Recent Advances in Plant-Mediated Zinc Oxide Nanoparticles with Their Significant Biomedical Properties. Bioengineering. Multidisciplinary Digital Publishing Institute; 2022;9:541. https://doi.org/ 10.3390/bioengineering9100541
11. Gatou M-A, Skylla E, Dourou P, Pippa N, Gazouli M, Lagopati N, et al., Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications. Crystals. Multidisciplinary Digital Publishing Institute; 2024;14:215. https://doi.org/10.3390/cryst14030215
12. Dheyab MA, Aziz AA, Moradi Khaniabadi P, Jameel MS, Oladzadabbasabadi N, Mohammed SA, et al., Monodisperse Gold Nanoparticles: A Review on Synthesis and Their Application in Modern Medicine. International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute; 2022;23:7400. https://doi.org/10.3390/ijms23137400
13. Sagadevan S, Imteyaz S, Murugan B, Lett JA, Sridewi N, Weldegebrieal GK, et al., A comprehensive review on green synthesis of titanium dioxide nanoparticles and their diverse biomedical applications. Green Processing and Synthesis. De Gruyter; 2022;11:44–63. https://doi.org/10.1515/gps2022-0005
14. Woźniak-Budych MJ, Staszak K, Staszak M. Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges. Molecules. Multidisciplinary Digital Publishing Institute; 2023;28:6687. https://doi.org/10.3390/molecules28186687
15. Arshad F, Naikoo GA, Hassan IU, Chava SR, El-Tanani M, Aljabali AA, et al., Bioinspired and Green Synthesis of Silver Nanoparticles for Medical Applications: A Green Perspective. Appl Biochem Biotechnol. 2024;196:3636–69. https://doi.org/10.1007/s12010-023-04719-z
16. Flieger J, Franus W, Panek R, SzymańskaChargot M, Flieger W, Flieger M, et al., Green Synthesis of Silver Nanoparticles Using Natural Extracts with Proven Antioxidant Activity. Molecules. Multidisciplinary Digital Publishing Institute; 2021;26:4986. https://doi.org/10.3390/molecules26164986
17. Gour A, and Jain NK. Advances in green synthesis of nanoparticles. Artificial Cells, Nanomedicine, and Biotechnology. Taylor & Francis; 2019;47:844–51. https://doi.org/10.1080/21691401.2019.157 7878
18. Ongtanasup T, Kamdenlek P, Manaspon C, Eawsakul K. Green-synthesized silver nanoparticles from Zingiber officinale extract: antioxidant potential, biocompatibility, anti-LOX properties, and in-silico analysis. BMC Complement Med Ther. 2024;24:84. https://doi.org/10.1186/s12906-024-04381- w
A. Johnsi Amala, Karthik Mohan. Phytochemical profiling, green synthesis, and characterization of Silver Nanoparticles from Momordica cymbalaria extract with promising Anti-Inflammatory and Antioxidant potential. Biomedicine: 2026, 46(1): 81-91