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Biomedicine

Volume: 44 Issue: 1

  • Open Access
  • Original Article

Exploring the association between PLGF and pregnancy outcomes

Nidhita M.N.1, Geetha Bhaktha2, Prashanth S.1

1Department of Obstetrics and Gynecology,

2Multidisciplinary Research Unit, Shimoga Institute of Medical Sciences, Shivamogga, 577 201, Karnataka, India

Corresponding author: Prashanth S. Email: [email protected]

Year: 2024, Page: 98-100, Doi: https://doi.org/10.51248/.v44i1.4113

Received: Dec. 6, 2023 Accepted: Feb. 11, 2024 Published: May 1, 2024

Abstract

Introduction and Aim: Pregnancy demands vigilant fetal monitoring, yet traditional methods have limitations, leading to research on biomarkers like placental growth factor (PLGF) to enhance predictive accuracy for adverse outcomes. This investigation focuses on assessing the relationship between PLGF levels and pregnancy outcomes in women with suspected preeclampsia.
Materials and Methods: A simple longitudinal design was employed, following pregnant women with suspected preeclampsia from enrollment until delivery. The study included 160 subjects, and their characteristics were recorded at admission. PLGF levels were measured, and pregnancy outcomes were assessed.
Results: Among the study population, the distribution of pregnancies showed that 45.62% were in the first pregnancy, 40% in the second pregnancy, 11.85% in the third pregnancy, and 2.5% in the fifth pregnancy. The highest PLGF levels were observed in the fifth pregnancy group.Analysis revealed that subjects with NICU admission had a lower mean PLGF value compared to those without NICU admission. Among subjects with low PLGF levels, the mean baby weight was lower by approximately 5.3% when match up to those with normal PLGF levels.Regarding blood pressure, subjects with decreased PLGF levels had a higher mean systolic blood pressure in contrast to those with normal PLGF levels.
Conclusion: Lower PLGF levels were associated with NICU admission, lower baby weight, and higher systolic blood pressure in women with suspected preeclampsia. These findings suggest that PLGF levels may have implications for pregnancy outcomes. Additional investigation with expanded sample sizes is necessary to authenticate these discoveries and look into the clinical relevance of PLGF in understanding and addressing preeclampsia.

Keywords: Biomarker; preeclampsia; PLGF.

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Cite this article

Nidhita M.N, Geetha Bhaktha, Prashanth S. Exploring the association between PLGF and pregnancy outcomes. Biomedicine: 2024; 44(1): 96-100.

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