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Biomedicine

Volume: 44 Issue: 1

  • Open Access
  • Review Article

Thymoquinone: A novel treatment option for triple negative breast cancer

Vani Mamillapalli1, Vinuthna Rallapalli1, Zyba Mohammed1, Dharani Motukuru 1, SRG Sowgandhika Kosuri3, Padmalatha Kantamaneni2 

1Dept. of Pharmaceutical Chemistry and Phytochemistry,

2Dept. of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, 521108, Andhra Pradesh, India 

3Dept. of Anesthesia, School of Health Sciences, NIMS University, Jugalapura, Jaipur, 332708, Rajasthan, India 

 

 Corresponding author: SRG Sowgandhika Kosuri. Email: [email protected] 

Year: 2024, Page: 13-20, Doi: https://doi.org/10.51248/.v44i1.4155

Received: Nov. 22, 2022 Accepted: Oct. 12, 2023 Published: April 24, 2024

Abstract

The most common treatment modes of cancer include chemotherapies along with other modes of treatment. But often resistance is developed and gruels towards the discovery of new modes of treatment for cancer. Natural products are used for ages in the treatment. One such component is thymoquinone (TQ). It has been extensively studied against cancer, especially in treating breast cancer. The review article updates its status on research against breast cancer and triple negative breast cancer. The paper describes various breast cancer (BC) treatment options in combination with TQ or alone such as heat shock 70-kDa protein 6 (HSPA6) situated on human chromosome in inhibition of BC growth, MMP-9 and MMP-2 as biomarkers in BC, use of cancer stem cells in vascular formation in solid tumor by VM (vascular mimicry) via MMP-2 and MT1-MMP genes upregulation, use of exosomes extracted from adipocyte-derived mesenchymal stem cells, cancer immunotherapy or immuno-oncology where natural killer lymphocyte cells are used to enhance innate immune response against tumors and pathogens, use of (TRAIL) tumor necrosis factor-related apoptosis-inducing ligand agonists, drugs with synergistic activity, identifying targeted genes IL17RD, and diet having natural molecules that can act potentially against cancer. The article also updates on research associated with TQ in overcoming hindrances related to its poor bioavailability making it an effective clinically acting drug molecule. Recent research indicates that TQ can be a successful candidate to eradicate cancer through its clinical interventions followed by drug design studies. 

 

Keywords: Thymoquinone; triple negative breast cancer; therapy.

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Cite this article

 Vani Mamillapalli, Vinuthna Rallapalli, Zyba Mohammed, Dharani Motukuru, SRG Sowgandhika Kosuri, Padmalatha Kantamaneni.      Thymoquinone: A novel treatment option for triple negative breast cancer. Biomedicine: 2024; 44(1): 13-20 

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