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Volume: 44 Issue: 1

  • Open Access
  • Original Article

Variation of ABO phenotypes, Rhesus factor and salivary secretor status in chronic periodontitis patients with and without type II diabetes mellitus: A cross sectional study

Samjotha Dharma1, Sahana Purushotham1, Sreeraj Surendran


1Department of Periodontology, A J Institute of Dental Sciences, Mangalore, Karnataka, India 

2A J Research Centre, A J Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India 


 Corresponding author: Sreeraj Surendran. Email: [email protected] 

Year: 2024, Page: 125-130, Doi: https://doi.org/10.51248/.v44i1.3893

Received: Dec. 11, 2023 Accepted: Feb. 21, 2024 Published: May 1, 2024



Introduction and Aim: While numerous studies have explored the connection between ABO blood groups and disease incidence in various medical contexts, there has been a scarcity of research dedicated to examining the relationship between ABO blood groups and the occurrence of oral diseases with a specific focus on those with and without Type II diabetes mellitus. Understanding the patient’s blood group and salivary secretor status might help to create a new qualitative personalized approach in preclinical diagnosis and to develop preventive measures. Hence, this study delves into the correlation between ABO phenotypes, Rhesus factor, and salivary secretor status in chronic periodontitis patients, with and without Type 2 Diabetes Mellitus 

Materials and Methods: The study sample comprised 120 subjects aged between 35 and 60 years. Participants were categorized into three groups: Group A, consisting of patients with only chronic periodontitis; Group B, including patients with only Type II Diabetes Mellitus; and Group C, comprising individuals with both chronic periodontitis and Type II Diabetes Mellitus. Salivary secretor status was determined using the absorption elution method. 

Results: Group B showed the highest percentage of salivary secretors (97.5%), followed by group A (95%) and group C showed the least percentage of secretors (92.5%). Group B showed the least percentage of non-secretors (2.5%), Group A showed 5% and group C showed the highest percentage of non-secretors (7.5%). The common blood groups in Study Group A were O>B>A>AB. Similarly in Group B, the blood groups were B>O=A>AB and finally in Study Group C, the common blood groups were B>A>O>AB. Majority of the individuals were Rh Positive. 

Conclusion: The current study has identified a correlation between ABO phenotype, Rh phenotype, and secretor status among individuals with periodontitis, both with and without type 2 diabetes. 

Keywords: Periodontitis; salivary secretor status; blood group; diabetes mellitus.



  1. Pai, G.P., Dayakar, M.M., Shaila, M., Dayakar A. Correlation between “ABO” blood group phenotypes and periodontal disease: Prevalence in south Kanara district, Karnataka state, India. J. Indian Soc Periodontol. 2012;16:519-523. 
  2. Vivek, S., Jain, J., Simon, S.P., Battur, H., Supreetha, S., Haridas R. Association of ABO Blood Group and Rh factor with periodontal disease in a population of Virajpet, Karnataka: A cross-sectional study. JIOH. 2013;5:30-34. 
  3. Preshaw, P.M., Alba, A.L., Herrera, D., Jepsen, S., Konstantinidis, A., Makrilakis, K., et al., Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55:21-31. 
  4. Mitra, R., Mishra, N., Rath, G.P. Blood groups systems. Indian J. Anaesth. 2014;58:524-528. 
  5. Metgud, R., Khajuria, N., Mamta, G.R. Evaluation of the secretor status of ABO blood group antigens in saliva among Southern Rajasthan population using absorption inhibition method. J. Clin. Diagn. 2016;10:ZC01-03. 
  6. Waseem, A.G., Iqbal, M., Khan, O.A., Tahir, M. Association of diabetes mellitus with ABO and Rh blood groups. Ann Pak Inst Med Sci. 2012;8:134-136. 
  7. Kinane, D.E., Bartold, P. Clinical relevance of the host responses of periodontitis. Periodontol. 2000. 2007;43:278-293. 
  8. Aravind, T., Neela, N., Mannava, P., Chidrawar, S.K., Karda, K., Gupta, S. Evaluation of correlation between periodontitis and ABO blood grouping-a clinical study. J Adv Med Dent Sci Res. 2016;4:78-82. 
  9. Campi, C., Escovich, L., Valdés, V., García, Borrás, S., Racca, L., Racca, A., et al., Secretor status and ABH antigens expression in patients with oral lesions. Medicina Oral, Patología Oral y Cirugía Bucal. 2007;12:431-434. 
  10. Dabelsteen, E., ABO blood group antigens in oral mucosa. What is new?. J. Oral Pathol. Med. 2002;31:65-70. 
  11. Yamakami, K. The individuality of semen with reference to its property of inhibiting specifically isohemoaglutination, J. Immunology.1926;12:185-189. 
  12. Lehrs, H., Tiber die grupperspezifisch eigenschaften des menschlichen speichels, Z, Immun Forsch. 1930;66:175-192. 
  13. Race, R. R., Sanger, R. Blood groups in man. Blackwell Scientific Publication, P, 1970:291. 
  14. Mohn, J.F., Owens, N.A., Plunkett, R.W. The inhibitory properties of group A and B non-secretor saliva. Immunological communications. 1981;10:315-340. 
  15. Abegaz, S.B. Human ABO blood groups and their associations with different diseases. Biomed Res. Int. 2021;23;1-9. 
  16. Khan, K.P., Pandey, V., Kumar, M., Singh, N., Singh, S., Kumari, P. Correlation between periodontal disease, ABO blood groups and their secretor status. Int. J. Sci. Res. 2018; 7:48-53. 

  17. Gill, J.C., Endres-Brooks, J., Bauer, P.J., Marks, W.J., Montgomery, R.R. The effect of ABO blood group on the diagnosis of von Willebrand disease. Blood. 1987;69:1691-1695. 
  18. Barbalic, M., Dupuis, J., Dehghan, A., Bis, J.C., Hoogeveen, R.C., Schnabel, R.B., et al., Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Human Molecular Genetics. 2010;19:1863-1872. 
  19. Pradhan, A.C., Chawla, T.N., Samuel, K.C., Pradhan, M.S. The relationship between periodontal disease and blood groups and secretor status. J. Periodontal Res.1971;6:294-300. 
  20. Koregol, A.C., Raghavendra, M., Nainegali, S., Kalburgi, N., Varma, S. ABO blood groups and Rhesus factor: An exploring link to periodontal diseases. Indian J Dent Res. 2010;21:364-368. 
  21. Demir, T., Uslu, H., Orbak, R., Al Toparlak, Ü., Ayyildiz, A. Effects of different blood groups on the reproduction of periodontal pocket bacteria. Int. Dent. J. 2009;59:83-86. 
  22. Sharma, S., Kumar, J., Choudhary, R., Soni, N.D. Study of association between ABO blood groups and diabetes mellitus. Sch J App Med Sci. 2014;2:34-37. 
  23. Aggarwal, T., Singh, D., Sharma, B., Shafi, Siddiqui, S., Agarwal, S. Association of ABO and Rh blood groups with type 2 diabetes mellitus in Muzaffarnagar city. Natl J Physiol Pharm Pharmacol. 2018;8:167-170. 
  24. Shrestha, S., Jha, S., Deep, G. Case control study of ABO blood group and Rhesus (Rh) factor in type 2 Diabetes Mellitus. Indian J. Appl. Res. 2014;4:1-3. 

Cite this article


Samjotha Dharma, Sahana Purushotham, Sreeraj Surendran. Variation of ABO phenotypes, Rhesus factor and salivary secretor status in chronic periodontitis patients with and without type II diabetes mellitus: A cross sectional study . Biomedicine: 2024; 44(1): 125-130